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Published on May 8th, 2017 | from CAMH

Understanding the Genetics of Nicotine Dependence

By Chidera Chukwueke, Pharmacology M.Sc Candidate, U of T  and Andrew Fares, Undergraduate Thesis Student, U of T

Did you know that one in five deaths in Canada over the last decade can be attributed to smoking, according to Statistics Canada?

There is ample evidence that cigarette smoking is detrimental to one’s health in many ways. There are many treatment options available, but these don’t work for everyone. In order to improve these treatment options, it is crucial to understand how our genes are associated with nicotine dependence.

Previous studies have shown that different versions of certain genes play a role in nicotine dependence. Our group is conducting research in order to expand on the current knowledge, and possibly advance clinical treatment options.

We are looking for healthy participants with no current drug use who are regular smokers. The goal of the study is to determine the relationship between the previously studied genes and different aspects of nicotine dependence.

The study includes drawing blood for genetics and three (or more) sessions, during which laboratory experiments and questionnaires will be completed. The total time commitment is about 12 hours.

  1. A screening assessment (2 hours)
  2. A laboratory session looking at your choices between 2 different cigarettes (approximately 5 hours)
  3. A laboratory session looking at how you respond to different objects (approximately 5 hours)

You will be compensated for your time and inconvenience during participation in this study.

Please use the following QR code/link to complete an eligibility survey. Eligible participants will be contacted by study staff: Code: 4EFC7AXYE

General inquiries

For inquiries about the study, contact us at: 416-535-8501 ext. 31564 or


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